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Oral Protocols: Daily oral doses of 1, 5, 10, 20, and 30 mg were evaluated over 12 weeks
Serum B12 reference ranges vary between laboratories, but generally, levels below 148 pmol/L are considered deficient, whilst levels between 148258 pmol/L are regarded as borderline and may warrant further investigation or a trial of treatment, particularly if symptoms are present
Safety and evidence level: what is and isnt known In the mouse obesity study, systemic administration of the NNMT inhibitor reduced body weight, white-adipose mass and plasma cholesterol without changing food intake and without any observable adverse effects over the study period
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Research examines its effects on NNMT activity, NAD+ homeostasis, metabolic pathway utilization, energy expenditure, and adipose-tissue endpoints independent of feeding-behavior changes
However, it can be managed by taking B12 supplements daily
